… along with the T cell-mediated cytotoxicity of CAFs were … target cancer cells through
virus-mediated oncolysis and to re-… the genome of the oncolytic adenovirus ICO15K to express a …

… less cytotoxic to non-cancer cells but increase their ability to … The replication of oncolytic
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …

… On-target off-tumor toxicity as a safety concern of redirecting … slices derived from prostate
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…

… primary T cell activation and T cell-mediated cytotoxicity … Fajardo et al. engineered an
oncolytic adenovirus, ICOVIR-… the efficacy of OV-BiTE in cancer biopsies. However, the lack of a …

… supported bystander cell-mediated cytotoxicity. In two distinct … Indeed, treatment of fresh
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …

… The goal of this review is to provide an introduction into the … T cells to cancer cells are
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …

… ) presentation, T-cell proliferation, activation, and cytotoxicity against … presentation across
multiple biopsies. This observation … oncolytic adenovirus, EnAd, to express TAM-targeting T cell …

… T-cell-engaging bispecific antibodies (bsAbs) are emerging as a … in xenograft models and
an oncolytic adenovirus encoding a CD3-… So-called “on-target, off-tumor toxicity” might limit the …

… To avoid “on-target off-tumour” toxicities, we have explored … (EnAd), an oncolytic
adenovirus in Phase I/II clinical trials. … approaches to redirect T cell toxicity towards cancer-supporting …

… cancer (OC) is related to the action of infiltrating cytotoxic T … In this study, we tested the
hypothesis that bispecific T-cell … in the biopsy of all tested patients tested positive for PD1 …